Cytotoxic Effect of Snake (Echis Carinatus) Venom on Human Embryonic Kidney Cells (HEK 293)

Cytopathic Effect of Snake (Echis Carinatus) Venom on Human Embryonic Kidney Cells

cytopathic effect of snake (echis carinatus) venom on human embryonic kidney cells

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Evaluation of Iranian Snake ‘Macrovipera lebetina’ Venom Cytotoxicity in Kidney Cell Line HEK-293

Background:Envenomation by Macrovipera lebetina (M. lebetina) is characterized by prominent local tissue damage, hemorrhage, abnormalities in the blood coagulation system, necrosis, and edema. However, the main cause of death after a bite by M. lebetina has been attributed to acute renal failure (ARF). It is unclear whether the venom components have a direct or indirect action in causing ARF. T...

Characterization of crude Echis carinatus venom-induced cytotoxicity in HEK 293T cells

Echis carinatus (saw-scaled viper) produces potent hemorrhagic venom that causes the development of apoptotic and necrotic tissues. In this study, we used polyethyleneimine (PEI) to enhance cellular adherence, and to determine whether the substrate attachment influenced the survival of cells treated with crude E. carinatus venom. Human embryonic kidney (HEK) 293T cells were grown for 18hr in ti...

The Effects of Bezoar on the Echis carinatus Snake Venom Poisoning in Mice

The Bezoar, a dense material found in the stomach of wild goat, is widely used against various diseases including snakebite in traditional medicine among the southeast tribes of Iran. This study was performed to evaluate the Bezoar effect on experimental mice receiving 2% and 10% concentrations of natural crude of Echis carinatus snake venom. Various doses of Bezoar (6, 50, 100 & 200 mg/kg/i....